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Common Side Effects Injection site reactions Headache Flushing Mild fluid retention Metabolic and Hormonal Considerations Potential alterations in glucose metabolism Elevated IGF-1 levels Theoretical risk of promoting tumor growth in predisposed individuals Key Limitation Most safety data comes from: Pediatric GH deficiency populations Adults with endocrine disorders There is limited long-term data in healthy, high-performing athletes

There's evidence it upregulates growth factor receptors, modulates nitric oxide, and influences the way fibroblasts (the cells that lay down collagen) organize and migrate

2020 Nov 17;53(5):1078-1094.e7

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